演題詳細

一般口演 / Oral Session

一般口演 25 (Oral Session 25) :CML:基礎 2

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日程
2013年10月11日(金)
時間
14:25 - 15:25
会場
第7会場 / Room No.7 (ロイトン札幌 2F リージェント)
座長・司会
中前 博久 (Hirohisa Nakamae):1
1:大阪市立大学大学院医学研究科 血液腫瘍制御学
 
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Long-term up-regulation of effector NK cells in CML after stopping imatinib

演題番号 : OS-1-126

片桐 誠一朗 (Seiichiro Katagiri):1、溝口 出 (Izuru Mizoguchi):2、善本 隆之 (Takayuki Yoshimoto):2、大屋敷 純子 (Junko H. Ohyashiki):3、田内 哲三 (Tetsuzo Tauchi):1、猪口 孝一 (Koichi Inokuchi):4、大屋敷 一馬 (Kazuma Ohyashiki):1

1:Department of Hematology, Tokyo Medical University、2:Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University、3:Department of Molecular Oncology, Institute of Medical Science, Tokyo Medical University、4:Department of Hematology, Nippon Medical School

 

Background: Recently, it has been found that some chronic myeloid leukemia (CML) patients with complete molecular response (CMR) are able to maintain CMR after imatinib (IM) stopping. We have reported that CML pts with sustained CMR after IM discontinuation had an increasing number of natural killer (NK) cells. This finding suggests that immunological surveillance may have some effects in maintaining CMR after discontinuation of IM. Method: To identify the long-term immunological effects of CML pts after IM discontinuation, we characterized their immunophenotypic profiles. We compared the profiles of CML pts who received IM with CMR for > 2 consecutive years (CMR group), those who could not sustain CMR but maintained a major molecular response (fluctuating CMR group), those who sustained CMR after discontinuing IM (STOP-IM group), and healthy volunteers (control group). Some pts in the STOP-IM group were analyzed sequentially. Results: The percentage of effector populations of NK cells was significantly higher in the CMR and STOP-IM groups than in the fluctuating CMR group. In the STOP-IM group, the elevated percentage (approximately >10%) of interferon (IFN)-γ+ NK cells was maintained for more than 12 months after discontinuing IM. Summary: Sustained higher activation levels of NK cells in CMR pts might be an immunological criterion for determining whether to stop IM.

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