演題詳細

ポスター / Poster

ポスター 8 (Poster 8) :AML:治療成績

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
政氏 伸夫 (Nobuo Masauji):1
1:北海道大学大学院保健科学研究院保健科学部門 病態解析学分野
 
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Clinical outcome and prognostic factors in elderly patients with de novo acute myeloid leukemia

演題番号 : PS-1-54

松井 宏行 (Hiroyuki Matsui):1、酒井 和哉 (Kazuya Sakai):1、村主 啓行 (Hiroyuki Muranushi):1、岡本 裕介 (Yusuke Okamoto):1、塚本 拓 (Taku Tsukamoto):1、山崎 尚也 (Naoya Yamasaki):1、杉浦 弘幸 (Hiroyuki Sugiura):1、上田 智朗 (Tomoaki Ueda):1、岡田 和也 (Kazuya Okada):1、城 友泰 (Tomoyasu Jo):1、大西 達人 (Tatsuhito Onishi):1、國富 あかね (Akane Kunitomi):1、上田 恭典 (Yasunori Ueda):1

1:Department of Haematology/Oncology, Kurashiki Central Hospital

 

(Introduction) Clinical outcome of the elderly patients with acute myeloid leukemia (AML) is so disappointing. (Patients and method) To illustrate clinical outcome and prognostic factors in elderly AML patients over age 70, we retrospectively analyzed evaluable 50 patients out of 54 patients diagnosed with AML at our hospital in the period from January, 2007 to August, 2012. Among these 54 cases, 2 cases that were treated another hospital and the other 2 cases that were in critical condition at diagnosis were excluded from the analysis. (Results) The median age was 77 years (Range 70-90). Twenty six male patients and 24 female patients were included in this study. Intensive chemotherapy was performed in 23 patients and less intensive chemotherapy such as CAG (Low dose cytarabine+ aclarubicin+G-CSF) was performed in 23 patients. Four patients received only supportive therapy. Fourteen of 23 evaluable cases(60.8%) who received intensive chemotherapy had a complete remission(CR) and 11 of 21 evaluable cases(52.4%) who received less intensive chemotherapy had a CR. 1-year overall survival(OS) of intensive and less intensive chemotherapy group were 60.7% and 35.2% respectively and 3-year OS were 18.9% and 16.1% respectively. There is no statistically significant difference between the two groups. A univariate analysis revealed that PS, poor cytogenetic risk and induction failure to CR were poor prognostic factors. (Conclusion) Clinical outcome of elderly AML patients in our hospital is not promising. Effective treatment especially for poor cytogenetic risk group is needed.

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