演題詳細

一般口演 / Oral Session

一般口演 3 (Oral Session 3) :AML:再発・難治性AML

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日程
2013年10月11日(金)
時間
09:30 - 10:30
会場
第4会場 / Room No.4 (さっぽろ芸文館 3F 黎明)
座長・司会
市川 幹 (Motoshi Ichikawa):1
1:湘南東部総合病院・クリニック 血液・腫瘍内科
 
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WT1 mRNA level in peripheral blood at first remission in AML is not related to relapse

演題番号 : OS-1-11

竹内 一人 (Kazuto Takeuchi):1、板楠 今日子 (Kyoko Itakusu):1、中瀬 浩一 (Koichi Nakase):1、名和 由一郎 (Yuichiro Nawa):1、原 雅道 (Masamichi Hara):2

1:Division of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan、2:Hematology Center, Takanoko Hospital, Matsuyama, Japan

 

[Introduction] WT1 mRNA is widely used as a monitoring marker of minimal residual disease (MRD) in acute myeloid leukemia (AML). To elucidate usefulness as a prognosis predictive factor of the WT1 mRNA level in AML, we performed retrospective study at our institution. [Methods] We studied 28 newly diagnosed AML patients who had measured the expression level of WT1 mRNA in peripheral blood before and after induction therapy in our department between July 2008 and November 2010. [Results] WT1 mRNA level at diagnosis is not related to relapse rate and overall survival. The number of the patients who achieved complete remission (CR) after the first induction therapy is 19, and eight of them relapsed. After achieving CR, 5 patients were negative (less than 50 copies/μg RNA) and 14 patients were positive (more than 50 copies/μg RNA) for WT1. The relapse rate of the WT1 negative and positive patients was 40% (2/5) and 42% (6/14), respectively, which showed no statistically significant difference. There was no significant relationship between the relapse rate and the rate of decrease of the amount of WT1 mRNA expression before and after induction therapy. After consolidation therapy, the relapse rate of the WT1 negative and positive patients was 10% (1/10) and 50% (2/4), respectively. [Conclusion] WT1 mRNA level in peripheral blood at first remission in AML is not related to relapse. However, it is suggested that WT1 mRNA level after consolidation therapy is related to relapse.

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