演題詳細

ポスター / Poster

ポスター 3 (Poster 3) :鉄キレート療法 (Iron Chelate Therapy)

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日程
2013年10月11日(金)
時間
16:50 - 17:50
会場
ポスター会場 / Poster (ロイトン札幌 3F ロイトンホールABCD)
座長・司会
藤島 眞澄 (Masumi Fujishima):1
1:秋田大学医学部 血液・腎臓・膠原病内科学
 
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Cardiovascular complications of thalassemia patients in iron chelation era

演題番号 : PS-1-14

Adisak Tantiworawit:1、Suebsakul Tapanya:1、Arintaya Phrommitikul:1、Ekarat Rattarittamrong:1、Chatree Chai-adisaksopha:1、Weerasak Nawarawong:1、Sasinee Hantrakool:1、Lalita Norasetthada:1

1:Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

 

Background: Cardiac complications are the most common cause of death in thalassemia. In the past, the incidence was high at 71%. Iron chelation is given to patients with iron overload to prevent these complications. This study aims to evaluate the prevalence and the correlation between risk factors in iron chelation era. Method: This is a cross sectional study from June 2011- May 2012. All thalassemia aged>15 years old were enrolled. Clinical data and Hb typing were reviewed. Echocardiography and CMR T2* were used to evaluate cardiac complications. Results: Ninety one patients were enrolled, 63.7% were females, median age 31 (16-75). There was 49.5 % homozygous β thalassemia, 31.9% β thalassemia/Hb E disease, 18.7% Hb H disease. Half of patients were transfusion dependent and 63.7% underwent splenectomy, 83.5% received iron chelation and mean ferritin was 3,820 ng/ml for the whole group. CMR T2* was more sensitive in detecting cardiac function. The CMR T2* showed shorter signal (≤ 20 msec) in 11.1%. Only 8.2% had impaired ejection fraction <55% by echocardiography. The CMR T2* ≤ 20 msec was significant correlated with higher maximum ferritin 5,739.14 ng/ml compared to 3,614 ng/ml (p=0.001). Pulmonary hypertension was found 7 patients (12.7%) and 71.42% had underwent splenectomy.

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