演題情報

学会・委員会企画

開催回
第59回・2014年・神戸
 

Some epidemiologic, clinical, subclinical features and renal histological lesions of lupus nephritis

演題番号 : GI-10-2-5

Pham Va Bui:1

1:University of Medicine Pham Ngoc Thach, Viet Nam

 

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease affecting multiple organs. The kidney appears to be the most commonly affected, occurring in 60-75% of cases with SLE. The presence and extent of kidney involvement greatly influence the long-term outcome of the disease. The aim of this study to evaluate the correlation between some clinical features and WHO classifications of lupus nephritis (LN) in patients managed and followed at the Department of Nephrology and Urology, 115 People’s Hospital.
Patients and Method: This was a “descriptive cross-sectional” study of patients from 02/2004 to 02/2007.
Results: Of 40 LN studied, 87.5% were women. In the majority of cases (70%), LN developed within 1 year of SLE diagnosis. The three most common clinical manifestations were edema (92.5%), hypertension (47.5%) and pallor (55%). There were 85% patients having Hb<12g/dl; 71.1%, hypoproteinemia; 81.6%, hypoalbuminemia; 87.5%, hematuria; 35%, nephrotic range proteinuria; 92.5%, positive ANA test and 72.5%, low C3 level. Class IV was the most common glomerular lesion (70%), following were class II and III (10%), class I (7.5%), class V (2.5%). There was a significant correlation between several features such as: hypoproteinemia, hypoalbuminemia, hematuria, proteinuria over 3.5g (nephrotic range), low C3 level and histological types(P<0.05); these abnormalities were more common in class IV.
Conclusion: All patients with SLE should be closely followed up for early diagnosis of LN by using urine analysis, and cast. Renal biopsy should be done in all patients with LN (or SLE patients in suspect of LN) if there is no contraindication.

前へ戻る