演題情報

学会・委員会企画

開催回
第59回・2014年・神戸
 

Calcium-phosphorus and PTH disorders in patients on chronic hemodialysis

演題番号 : GI-10-2-3

Pham Va Bui:1

1:University of Medicine Pham Ngoc Thach, Viet Nam

 

Introduction:Disorders of Calcium, Phosphorus and PTH metabolism are very common in patients on chronic hemodialysis, resulting in secondary hyperparathyroidism, vascular and tissue calcification, renal osteodystrophy, clinical symptoms and increasing the mortality.
Objectives: The study was aimed at determining the proportions of serum Ca-P and PTH disorders,and the correlation between these disorders and some clinical symptoms (arthrosis, prupritus, numbness, and muscle weakness, clonus or pain) in hemodialysis patients.
Subjects and method:This was a cross-sectional study of 80 patients on chronic hemodialysis in the Department of Nephro-Urology, 115 People Hospital from 30/1/2007 to 30/6/ 2007.
Results: The mean values of serum Ca, P, and PTH levels and of Ca x P product were 8.38 ± 1.14 mg/dL, 16.92± 8.82 mg/dL, 251.42 ± 352.51 pg/mL and 140.42 ± 73.31 mg2/dL2 respectively. Low serum calcium (defined as < 8.4 mg/dl) was observed in 63.75% of patients, whereas high serum calcium (defined as > 10.2 mg/dL) in 8.75% of patients. Low serum phosphate rate (defined as < 3.5 mg/dL) was 5% , whereas high serum phosphate (> 5.5 mg/dL) rate was 91.25%. Only 11.25% of patients got the recommended Ca x P product level (defined as < 55 mg2/dL2 ). 23.75% and 57.5% of patients had the serum PTH level>300 pg/mL and<150 pg/mL respectively. There was a correlation between PTH level>300 pg/mL and clinical symptoms, and between PTH <150 pg/mL and prupritus, muscle pain, clonus and weakness(Fisher’s exact test, p< 0.05) whereas there was no a correlation between low serum calcium or high serum phosphate and clinical symptoms(Fisher's exact test, p> 0.05). 88.75% of patients were treated by vitamin D supplement.
Conclusions:Ca-P and PTH disorders were very common in hemodialyzed patients, and usually neglected. Vitamin D was supplied to patients without adjustment to their serum Ca-P and PTH concentrations, and consequently resulting in the aggravation of the existing Ca-P and PTH disorders.

前へ戻る