演題情報

学会・委員会企画

開催回
第59回・2014年・神戸
 

The changing of residual renal function in adult patients on regular hemodialysis. A single-center study

演題番号 : GI-10-1-2

Pham Va Bui:1

1:University of Medicine Pham Ngoc Thach, Viet Nam

 

Background: Residual renal function(RRF) may help to predict the mortality , and the unfavorable clinical outcomes of patients on chronic dialysis.
Methods and Patients: We conducted an observational, descriptive, and prospective study of 54 patients on chronic hemodialysis in the Dialuysis Unit of the Nguyen Tri Phuong University Hospital in Ho Chi Minh City of Viet Nam, from July/ 2012 to July 2013. All patients were dialyzed 4-hours/session, thrice a week, with middle-flux Nipro dialyzers of 1.5 surface, bicarbonate dialysate. The RUV at study entry and its changes at the 3th, 6th, 9th month since study and their association with clinical features and other treatments were evaluated
Results: At study entry, the mean RUV was 847.17mL/24h ±357.63mL; patients with predialysis followup had higher RUV compared to whom without it (936.7mL/24h ± 327.4mL vs 709.2 ± 360.3mL; t test, p= 0.01). The RUV at the 3th, 6th, 9th since study was 677.32mL/24h ± 336.44mL, 526.85mL/24h ±325.17mL, 404.26mL/24h ±308.36mL respectively(2 dependent sample t- test,p<0.001). Chronologically, there was an statistically significant correlation between the RUV decline and dyspnea, edema, arterial hypertension, hypertesion stages, deteriotion of the ejection fraction,and the increasing in hsCRP at 3th, 6th, 9th month(χ2 test, p=0.01 - < 0.001). Loop diuretics helped preserving RUV (χ2 test, p at 3th, 6th, 9th month was 0.11, 0.029, 0.003 respectively) whereas patients taking β-blockers lost RUV faster(t test, p at 6th, 9th month was 0.02, 0.026 respectively)). There was no correlation between intradialytic hypotension and RUV(χ2 test, p at 3th, 6th, 9th month was 0.18, 0.34, 0.27 respectively)
Conclusions:There was a decline in RUV during chronic hemodialysis, and the correlation between this phenomenon and the unfavorable clinical outcomes. Loop diuretics appeared one of the benificial drugs in preserving RUV.

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