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学会・委員会企画

開催回
第56回・2011年・横浜
 

Association of Circulating Fractalkine (CX3CL1) and CX3CR1+CD4+T Cell with Common Carotid Artery Intima-Media Thickness in Chronic Kidney Disease

演題番号 : GI-9-3-3

Ashok K Yadav:1、Vivekanand Jha:1

1:Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

 

Fractalkine (CX3CL1), a chemokine expressed on the surface of endothelial cells, and its receptor (CX3CR1) expressed on T lymphocytes have been shown to be abnormal in atherosclerosis. We investigated whether the CX3CL1 level and CX3CR1 expression was altered in patients with chronic kidney disease (CKD) and its association with intima-media thickness. CX3CR1 expression on CD4+ T cell was analysed using flowcytometry in 62 healthy controls (HC) and 102 CKD patients (37 pre-dialysis, 32 hemodialysis and 33 peritoneal dialysis patients). Fractalkine and highly sensitive C-reactive protein (hsCRP) were analysed by ELISA. Common carotid artery intima-media thickness (CCA-IMT) was measured by ultrasound. Compared to HC, CKD patients exhibited 2.5-fold increase in the CD4+CX3CR1+ cells (15.19%±1.3% Vs 5.9±0.34, p <0.0001). Fractalkine (pg/ml) and hsCRP (μg/ml) levels were also increased in CKD subjects (502.5± 63.9 Vs 239.7 ±9.67, p <0.0004, and 103±6.5 Vs 51.77±8.5, p <0.0001), as was the CCA-IMT (0.71±0.01 Vs 0.56±0.01mm, p=0.0001). IMT correlated positively with CD4+CX3CR1+cells (r=0.42, p <0.0001), fractalkine (r=0.28, p=0.004) and age (r=0.37, p, 0.001). There was a significant relationship between the CD4+CX3CR1+ cells and fractalkine (r=0.21, p=0.04). CKD subgroup analysis did not show difference in CD4+CX3CR1+cells, fractalkine level, and IMT whereas hsCRP was higher in MHD patients compared to PD and pre-dialysis patients (115.9±10.75 μg/ml, 114.4±9.4 μg/ml and 80.73± 12.4 μg/ml, p=0.04). CKD subjects show increase in CD4+CX3CR1+ cells population, plasma fractalkine and IMT; the association of CD4+CX3CR1+ cells and plasma fractalkine with CCA-IMT indicates that CX3CL1-CX3CR1 may be important in development and/or progression of atherosclerosis in CKD.

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