An attempt to identify the effects of melatonin on hippocampal synaptic plasticity with the Bayesian approach

[Speaker] Takahashi, Yoshiyuki:1
[Co-author] Okada, Takashi:2, Sawa, Kosuke:1
1:Senshu University (Japan), 2:Sophia University (Japan)

Hippocampal long-term depression (LTD) plays an important role in learning and memory. A pineal hormone, melatonin, which is mainly secreted at night, may regulate hippocampal synaptic plasticity. In this study, extracellular synaptic responses were recorded electrophysiologically from rat hippocampal slices, and LTD was induced by low frequency stimulation or chemical application. The degree of LTD was enhanced by melatonin in the low frequency stimulation condition. We constructed a mathematical model of synaptic plasticity with parameters named EARLY and LATE. EARLY was set to gradually increase after the LTD induction while LATE was set to gradually decrease. Posterior distributions of LATE, estimated by Bayesian manner, were enhanced by melatonin; however, those of EARLY were not. Moreover, the estimation values calculated by these posterior distributions were close to actual measurement values. Physiological candidates for the two parameters should be identified.
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